Fluoroquinolone Pharmacodynamics

Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis.

We examined the impact of dose fractionation and altered MICs on survivorship in a neutropenic rat model of Pseudomonas aeruginosa sepsis employing the new fluoroquinolone antibiotic lomefloxacin. Once-daily administration of a drug dose which produced a high peak concentration/MIC (peak/MIC) ratio (ca. 20/1) produced significantly better survivorship compared with regimens employing the same d...

Etymologia: Fluoroquinolone

Pharmacokinetics/ Pharmacodynamics

Factors Influencing Fluoroquinolone Resistance

no. ISTN3X; 96% identical), comprising one of Tn3-like inverted repeats and putative coding regions for transposase, resolvase (also called repressor), and ampicillin resistance. The resistance gene encodes a TEM-1 type β-lactamase. (The sequence has been registered to DDBJ/GenBank/ EMBL with accession no. AB103092.) Conjugative transferability of p981123 between S. Enteritidis strains was exam...

Fluoroquinolone-resistant Streptococcus pneumoniae

To the Editor: In pneumococci, resistance to fluoroquinolones is associated with chromosomal mutations in the quinolone-resistance–determining regions (QRDR) of type II topoiso-merase enzymes, predominantly gyrA and parC. Several mutations have been described in these enzymes, but only a few have been shown by in vitro studies to confer resistance: S81F or Y, C, or I and E85K in gyrA; E474K in ...